Research background
2018 : Habilitation for research direction (HDR), University of Strasbourg, France
Since 2013: CNRS researcher (Chargé de recherche) at IPCMS, University of Strasbourg, France
2011 – 2013: Postdoctoral fellowship, INSERM and IHU Strasbourg
2009 – 2011 : Postdoctoral fellowship, University of Melbourne, Australia,
Academic background
2008 : PhD in Physical Chemistry, University of Strasbourg
2005 : M.Sc. in Polymers, Materials and Surfaces, University of Strasbourg
Current research
I develop my research activity at IPCMS, Strasbourg, CNRS UMR 7504, working on the synthesis and functionalization of nanoparticles for health applications. My research topics include:
- Protein–based nanocarriers via mesoporous silica templating for drug delivery applications
- Functional mesoporous nanosilica for bioimaging and biodepollution applications.
- Magnetic core-shells for MRI, magnetic hyperthermia and drug delivery
- NIR-light responsive mesoporous silica coated carbon-based materials for phototherapy and drug delivery
Publications
[1]
C. Wells, O. Vollin-Bringel, V. Fiegel, S. Harlepp, B. Van der Schueren, S. Bégin-Colin, D. Bégin, D. Mertz, Engineering of Mesoporous Silica Coated Carbon-Based Materials Optimized for an Ultrahigh Doxorubicin Payload and a Drug Release Activated by pH, T, and NIR-light, Advanced Functional Materials. 28 (2018) 1706996. https://doi.org/10.1002/adfm.201706996.
[1]
X.-Y. Wang, D. Mertz, C. Blanco-Andujar, A. Bora, M. Menard, F. Meyer, C. Giraudeau, S. Bégin-Colin, Optimizing the silanization of thermally-decomposed iron oxide nanoparticles for efficient aqueous phase transfer and MRI applications, RSC Advances. 6 (2016) 93784–93793. https://doi.org/10.1039/c6ra18360c.
[1]
J. Wallyn, N. Anton, D. Mertz, S. Bégin-Colin, F. Perton, C.A. Serra, F. Franconi, L. Lemaire, M. Chiper, H. Libouban, N. Messaddeq, H. Anton, T.F. Vandamme, Magnetite- and Iodine-Containing Nanoemulsion as a Dual Modal Contrast Agent for X-ray/Magnetic Resonance Imaging, ACS Applied Materials & Interfaces. 11 (2019) 403–416. https://doi.org/10.1021/acsami.8b19517.
[1]
F. Vergnaud, X. Kesse, A. Jacobs, F. Perton, S. Bégin-Colin, D. Mertz, S. Descamps, C. Vichery, J.-M. Nedelec, Magnetic bioactive glass nano-heterostructures: a deeper insight into magnetic hyperthermia properties in the scope of bone cancer treatment, Biomaterials Science. 10 (2022) 3993–4007. https://doi.org/10.1039/d2bm00319h.
[1]
Y. Rosales-Cabara, G. Manfredi, G. Schnoering, P.-A. Hervieux, L. Mertz, C. Genet, Optimal protocols and universal time-energy bound in Brownian thermodynamics, Physical Review Research. 2 (2020) 012012. https://doi.org/10.1103/PhysRevResearch.2.012012.
[1]
P.D. Ramirez, C. Lee, R. Fedderwitz, A.R. Clavijo, D.P.P. Barbosa, M. Julliot, J. Vaz-Ramos, D. Begin, S. Le Calve, A. Zaloszyc, P. Choquet, M.A.G. Soler, D. Mertz, P. Kofinas, Y. Piao, S. Bégin-Colin, Phosphate Capture Enhancement Using Designed Iron Oxide-Based Nanostructures., Nanomaterials (Basel, Switzerland). 13 (2023) 587. https://doi.org/10.3390/nano13030587.
[1]
F. Perton, M. Palluel, C. Kiefer, B. Freis, D. Mertz, S. Bégin-Colin, One Pot Synthesis of Dithiolane Dendron Functionalized Gold Nanoparticles, European Journal of Inorganic Chemistry. 2021 (2021) 4286–4297. https://doi.org/10.1002/ejic.202100650.
[1]
F. Perton, G. Cotin, C. Kiefer, J.-M. Strub, S. Cianferani, J.-M. Greneche, N. Parizel, B. Heinrich, B. Pichon, D. Mertz, S. Bégin-Colin, Iron Stearate Structures: An Original Tool for Nanoparticles Design, Inorganic Chemistry. 60 (2021) 12445–12456. https://doi.org/10.1021/acs.inorgchem.1c01689.
[1]
F. Perton, S. Harlepp, G. Follain, K. Parkhomenko, J.G. Goetz, S. Bégin-Colin, D. Mertz, Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivo, Journal of Colloid and Interface Science. 542 (2019) 469–482. https://doi.org/10.1016/j.jcis.2019.01.098.
[1]
F. Perton, M. Tasso, G.A. Munoz Medina, M. Menard, C. Blanco-Andujar, E. Portiansky, M.B. Fernandez van Raap, D. Begin, F. Meyer, S. Bégin-Colin, D. Mertz, Fluorescent and magnetic stellate mesoporous silica for bimodal imaging and magnetic hyperthermia, Applied Materials Today. 16 (2019) 301–314. https://doi.org/10.1016/j.apmt.2019.06.006.
[1]
J.R. Orives, B.P. Pichon, D. Mertz, K. Sartori, S. Bégin-Colin, W.R. Viali, S.J. Lima Ribeiro, M. Nalin, Phosphate glasses containing monodisperse Fe3-delta O4@SiO2 stellate nanoparticles obtained by melt-quenching process, Ceramics International. 46 (2020) 12120–12127. https://doi.org/10.1016/j.ceramint.2020.01.257.
[1]
A. Mohanty, C.D. Viet, A.-C. Roger, A. Adam, D. Mertz, W. Baaziz, I. Janowska, Structural impact of carbon nanofibers/few-layer-graphene substrate decorated with Ni for CO2 methanation via inductive heating, Applied Catalysis B-Environmental. 298 (2021). https://doi.org/10.1016/j.apcatb.2021.120589.
[1]
D. Mertz, S. Harlepp, J. Goetz, D. Begin, G. Schlatter, S. Bégin-Colin, A. Hebraud, Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications, Advanced Therapeutics. 3 (2020) 1900143. https://doi.org/10.1002/adtp.201900143.
[1]
D. Mertz, O. Sandre, S. Bégin-Colin, Drug releasing nanoplatforms activated by alternating magnetic fields, Biochimica et Biophysica Acta-General Subjects. 1861 (2017) 1617–1641. https://doi.org/10.1016/j.bbagen.2017.02.025.
[1]
D. Mertz, C. Affolter-Zbaraszczuk, J. Barthes, J. Cui, F. Caruso, T.F. Baumert, J.-C. Voegel, J. Ogier, F. Meyer, Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging, Nanoscale. 6 (2014) 11676–11680. https://doi.org/10.1039/c4nr02623c.
[1]
D. Mertz, S. Bégin-Colin, Encapsulation and Release of Drugs from Magnetic Silica Nanocomposites, in: N. Thanh (Ed.), CLINICAL APPLICATIONS OF MAGNETIC NANOPARTICLES: DESIGN TO DIAGNOSIS MANUFACTURING TO MEDICINE / Edited by N.T.K. Thanh, 2018: pp. 161–172. 10.1201/9781315168258.
[1]
M. Menard, F. Meyer, C. Affolter-Zbaraszczuk, M. Rabineau, A. Adam, P.D. Ramirez, S. Bégin-Colin, D. Mertz, Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model, Nanotechnology. 30 (2019) 174001. https://doi.org/10.1088/1361-6528/aafe1c.
[1]
M. Ménard, F. Meyer, K. Parkhomenko, C. Leuvrey, G. Francius, S. Bégin-Colin, D. Mertz, Mesoporous silica templated-albumin nanoparticles with high doxorubicin payload for drug delivery assessed with a 3-D tumor cell model, Biochimica et Biophysica Acta (BBA) - General Subjects. 1863 (2019) 332–341. https://doi.org/10.1016/j.bbagen.2018.10.020.
[1]
S. Martinez de Lizarrondo, C. Jacqmarcq, M. Naveau, M. Navarro-Oviedo, S. Pedron, A. Adam, B. Freis, S. Allouche, D. Goux, S. Razafindrakoto, F. Gazeau, D. Mertz, D. Vivien, T. Bonnard, M. Gauberti, Tracking the immune response by MRI using biodegradable and ultrasensitive microprobes., Science Advances. 8 (2022) eabm3596. https://doi.org/10.1126/sciadv.abm3596.
[1]
B. Li, A. Adam, M. Criado-Gonzalez, L. Jierry, J. Bizeau, A. Chaumont, S. Harlepp, C. Melart, S. Bégin-Colin, D. Begin, D. Mertz, Near-infrared responsive nanocomposite hydrogels made from enzyme-coated carbon nanotubes@ large pore mesoporous silica for remotely triggered drug delivery, Materialia. 22 (2022) 101414. https://doi.org/10.1016/j.mtla.2022.101414.
[1]
B. Li, M. Criado-Gonzalez, A. Adam, J. Bizeau, C. Melart, A. Carvalho, S. Bégin, D. Begin, L. Jierry, D. Mertz, Peptide Hydrogels Assembled from Enzyme-Adsorbed Mesoporous Silica Nanostructures for Thermoresponsive Doxorubicin Release, ACS Applied Nano Materials. 5 (2022) 120–125. https://doi.org/10.1021/acsanm.1c03959.
[1]
B. Li, S. Harlepp, V. Gensbittel, C.J.R. Wells, O. Bringel, J.G. Goetz, S. Bégin-Colin, M. Tasso, D. Begin, D. Mertz, Near infra-red light responsive carbon nanotubes@mesoporous silica for photothermia and drug delivery to cancer cells, Materials Today Chemistry. 17 (2020) 100308. https://doi.org/10.1016/j.mtchem.2020.100308.
[1]
X. Kesse, A. Adam, S. Bégin-Colin, D. Mertz, E. Larquet, T. Gacoin, I. Maurin, C. Vichery, J.-M. Nedelec, Elaboration of Superparamagnetic and Bioactive Multicore–Shell Nanoparticles (γ-Fe2O3@SiO2-CaO): A Promising Material for Bone Cancer Treatment, ACS Applied Materials & Interfaces. 12 (2020) 47820–47830. https://doi.org/10.1021/acsami.0c12769.
[1]
K. Katcko, E. Urbain, F. Ngassam, L. Kandpal, B. Chowrira, F. Schleicher, U. Halisdemir, D. Wang, T. Scherer, D. Mertz, B. Leconte, N. Beyer, D. Spor, P. Panissod, A. Boulard, J. Arabski, C. Kieber, E. Sternitzky, V. Costa, M. Hehn, F. Montaigne, A. Bahouka, W. Weber, E. Beaurepaire, C. Kubel, D. Lacour, M. Alouani, S. Boukari, M. Bowen, Encoding Information on the Excited State of a Molecular Spin Chain, Advanced Functional Materials. 31 (2021) 2009467. https://doi.org/10.1002/adfm.202009467.
[1]
R. Hachani, M. Lowdell, M. Birchall, A. Hervault, D. Mertz, S. Bégin-Colin, N.T.K. Thanh, Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents, Nanoscale. 8 (2016) 3278–3287. https://doi.org/10.1039/c5nr03867g.
[1]
D.S.B. Gomes, L.G. Paterno, A.B.S. Santos, A. Garay V., D. Mertz, S.M. Freitas, M.A.G. Soler, New insights on the formation of gold nanoparticles and Pluronic nanocomposites: Kinetics and thermodynamics parameters, in: Journal of Molecular Liquids, 2018: pp. 181–189. https://doi.org/10.1016/j.molliq.2018.07.042.
[1]
F. Gelle, R. Chirita, D. Mertz, M.V. Rastei, A. Dinia, S. Colis, Guideline to atomically flat TiO2-terminated SrTiO3(001) surfaces, Surface Science. 677 (2018) 39–45. https://doi.org/10.1016/j.susc.2018.06.001.
[1]
B. Freis, M.D.L.Á. Ramírez, S. Furgiuele, F. Journe, C. Cheignon, L.J. Charbonnière, C. Henoumont, C. Kiefer, D. Mertz, C. Affolter-Zbaraszczuk, F. Meyer, S. Saussez, S. Laurent, M. Tasso, S. Bégin-Colin, Bioconjugation studies of an EGF-R targeting ligand on dendronized iron oxide nanoparticles to target head and neck cancer cells, International Journal of Pharmaceutics. 635 (2023) 122654. https://doi.org/https://doi.org/10.1016/j.ijpharm.2023.122654.
[1]
V. Fiegel, S. Harlepp, S. Bégin-Colin, D. Bégin, D. Mertz, Design of Protein-Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells, Chemistry-a European Journal. 24 (2018) 4662–4670. https://doi.org/10.1002/chem.201705845.
[1]
Z. Ferjaoui, S. Nahle, R. Schneider, H. Kerdjoudj, D. Mertz, F. Quiles, K. Ferji, E. Gaffet, H. Alem, Development of Folate-Superparamagnetic Nanoconjugates for Inhibition of Cancer Cell Proliferation, ADVANCED MATERIALS INTERFACES. (n.d.). https://doi.org/10.1002/admi.202202364.
[1]
Z. Ferjaoui, E.J. Al Dine, A. Kulmukhamedova, L. Bezdetnaya, C.S. Chan, R. Schneider, F. Mutelet, D. Mertz, S. Bégin-Colin, F. Quiles, E. Gaffet, H. Alem, Doxorubicin-Loaded Thermoresponsive Superparamagnetic Nanocarriers for Controlled Drug Delivery and Magnetic Hyperthermia Applications, ACS Applied Materials & Interfaces. 11 (2019) 30610–30620. https://doi.org/10.1021/acsami.9b10444.
[1]
P. Duenas-Ramirez, C. Bertagnolli, R. Muller, K. Sartori, A. Boos, M. Elhabiri, S. Bégin-Colin, D. Mertz, Highly chelating stellate mesoporous silica nanoparticles for specific iron removal from biological media, Journal of Colloid and Interface Science. 579 (2020) 140–151. https://doi.org/10.1016/j.jcis.2020.06.013.
[1]
M. Diana, P. Halvax, D. Mertz, A. Legner, J.-M. Brule, E. Robinet, D. Mutter, P. Pessaux, J. Marescaux, Improving Echo-Guided Procedures Using an Ultrasound-CT Image Fusion System, Surgical Innovation. 22 (2015) 217–222. https://doi.org/10.1177/1553350615577483.
[1]
G. Cotin, B. Heinrich, F. Perton, C. Kiefer, G. Francius, D. Mertz, B. Freis, B. Pichon, J.-M. Strub, S. Cianférani, N. Ortiz Peña, D. Ihiawakrim, D. Portehault, O. Ersen, A. Khammari, M. Picher, F. Banhart, C. Sanchez, S. Bégin-Colin, A Confinement-Driven Nucleation Mechanism of Metal Oxide Nanoparticles Obtained via Thermal Decomposition in Organic Media, Small. (2022) 2200414. https://doi.org/10.1002/smll.202200414.
[1]
G. Cotin, F. Perton, C. Blanco-Andujar, B. Pichon, D. Mertz, S. Bégin-Colin, Design of Anisotropic Iron-Oxide-Based Nanoparticles for Magnetic Hyperthermia, in: R. Fratila, J. DeLaFuente (Eds.), NANOMATERIALS FOR MAGNETIC AND OPTICAL HYPERTHERMIA APPLICATIONS / Editd by R.M. Fratila & J.M. De La Fuente, 2019: pp. 41–60. 10.1016/B978-0-12-813928-8.00002-8.
[1]
G. Cotin, C. Kiefer, F. Perton, M. Boero, B. Özdamar, A. Bouzid, G. Ori, C. Massobrio, D. Begin, B. Pichon, D. Mertz, S. Bégin-Colin, Evaluating the Critical Roles of Precursor Nature and Water Content When Tailoring Magnetic Nanoparticles for Specific Applications, ACS Appl. Nano Mater. 1 (2018) 4306–4316. https://doi.org/10.1021/acsanm.8b01123.
[1]
G. Cotin, C. Kiefer, F. Perton, D. Ihiawakrim, C. Blanco-Andujar, S. Moldovan, C. Lefèvre, O. Ersen, B. Pichon, D. Mertz, S. Bégin-Colin, Unravelling the Thermal Decomposition Parameters for The Synthesis of Anisotropic Iron Oxide Nanoparticles, Nanomaterials. 8 (2018) 881. https://doi.org/10.3390/nano8110881.
[1]
G. Cotin, C. Blanco-Andujar, F. Perton, L. Asin, J.M. de la Fuente, W. Reichardt, D. Schaffner, D.-V. Ngyen, D. Mertz, C. Kiefer, F. Meyer, S. Spassov, O. Ersen, M. Chatzidakis, G.A. Botton, C. Henoumont, S. Laurent, J.-M. Greneche, F.J. Teran, D. Ortega, D. Felder-Flesch, S. Bégin-Colin, Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications, Nanoscale. 13 (2021) 14552–14571. https://doi.org/10.1039/d1nr03335b.
[1]
G. Cotin, F. Perton, C. Petit, S. Sall, C. Kiefer, V. Begin, B. Pichon, C. Lefèvre, D. Mertz, J.-M. Greneche, S. Bégin-Colin, Harnessing Composition of Iron Oxide Nanoparticle: Impact of Solvent-Mediated Ligand-Ligand Interaction and Competition between Oxidation and Growth Kinetics, Chemistry of Materials. 32 (2020) 9245–9259. https://doi.org/10.1021/acs.chemmater.0c03041.
[1]
G. Cotin, C. Blanco-Andujar, D.-V. Nguyen, C. Affolter, S. Boutry, A. Boos, P. Ronot, B. Uring-Lambert, P. Choquet, P.E. Zorn, D. Mertz, S. Laurent, R.N. Muller, F. Meyer, D.F. Flesch, S. Bégin-Colin, Dendron based antifouling, MRI and magnetic hyperthermia properties of different shaped iron oxide nanoparticles, Nanotechnology. 30 (2019) 374002. https://doi.org/10.1088/1361-6528/ab2998.
[1]
B. Chowrira, L. Kandpal, M. Lamblin, F. Ngassam, C.-A. Kouakou, T. Zafar, D. Mertz, B. Vileno, C. Kieber, G. Versini, B. Gobaut, L. Joly, T. Ferté, E. Monteblanco, A. Bahouka, R. Bernard, S. Mohapatra, H. Prima Garcia, S. Elidrissi, M. Gavara, E. Sternitzky, V. Da Costa, M. Hehn, F. Montaigne, F. Choueikani, P. Ohresser, D. Lacour, W. Weber, S. Boukari, M. Alouani, M. Bowen, Quantum Advantage in a Molecular Spintronic Engine that Harvests Thermal Fluctuation Energy., Advanced Materials. Early access (2022) e2206688–e2206688. https://doi.org/10.1002/adma.202206688.
[1]
C. Blanco-Andujar, A. Walter, G. Cotin, C. Bordeianu, D. Mertz, D. Felder-Flesch, S. Bégin-Colin, Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia, Nanomedicine. 11 (2016) 1889–1910. https://doi.org/10.2217/nnm-2016-5001.
[1]
J. Bizeau, A. Adam, C. Nadal, G. Francius, D. Siniscalco, M. Pauly, S. Bégin-Colin, D. Mertz, Protein sustained release from isobutyramide-grafted stellate mesoporous silica nanoparticles., International Journal of Pharmaceutics: X. 4 (2022) 100130–100130. https://doi.org/10.1016/j.ijpx.2022.100130.
[1]
J. Bizeau, A. Adam, S. Bégin-Colin, D. Mertz, Serum Albumin Antifouling Effects of Hydroxypropyl-Cellulose and Pluronic F127 Adsorbed on Isobutyramide-Grafted Stellate Silica Nanoparticles, European Journal of Inorganic Chemistry. (2021) 4799–4805. https://doi.org/10.1002/ejic.202100678.
[1]
J. Bizeau, D. Mertz, Design and applications of protein delivery systems in nanomedicine and tissue engineering, Advances in Colloid and Interface Science. 287 (2021) 102334. https://doi.org/10.1016/j.cis.2020.102334.
[1]
M.O. Besenhard, L. Panariello, C. Kiefer, A.P. LaGrow, L. Storozhuk, F. Perton, S. Bégin, D. Mertz, N.T.K. Thanh, A. Gavriilidis, Small iron oxide nanoparticles as MRI T-1 contrast agent: scalable inexpensive water-based synthesis using a flow reactor dagger, Nanoscale. (2021). https://doi.org/10.1039/d1nr00877c.
[1]
C. Becker, J. Petersen, G. Mertz, D. Ruch, A. Dinia, High Superhydrophobicity Achieved on Poly(ethylene terephthalate) by Innovative Laser-Assisted Magnetron Sputtering, Journal of Physical Chemistry C. 115 (2011) 10675–10681. https://doi.org/10.1021/jp200517e.
[1]
A. Adam, S. Harlepp, F. Ghilini, G. Cotin, B. Freis, J. Goetz, S. Bégin, M. Tasso, D. Mertz, Core-shell iron oxide@stellate mesoporous silica for combined near-infrared photothermia and drug delivery: Influence of pH and surface chemistry, Colloids and Surfaces A-Physicochemical and Engineering Aspects. 640 (2022) 128407. https://doi.org/10.1016/j.colsurfa.2022.128407.
[1]
A. Adam, K. Parkhomenko, P. Duenas-Ramirez, C. Nadal, G. Cotin, P.-E. Zorn, P. Choquet, S. Bégin-Colin, D. Mertz, Orienting the Pore Morphology of Core-Shell Magnetic Mesoporous Silica with the Sol-Gel Temperature. Influence on MRI and Magnetic Hyperthermia Properties, Molecules. 26 (2021) 971. https://doi.org/10.3390/molecules26040971.