Jérémie LEONARD

Jérémie LEONARD

Directeur de Recherche, Optique Ultra-rapide et Nanophotonique (DON)Jeremie.Leonard@ipcms.unistra.fr
Tél: +33(0)3 88 10 72 43, +33(0)3 88 10 70 54Bureau: 2042

Parcours de recherche

Après une thèse et un post-doctorat dans le domaine des atomes froids et de la condensation de Bose-Einstein, j’ai été recruté en 2004 comme chargé de recherche au CNRS, dans le Département d’Optique ultrarapide et Nanophotonique (DON) de l’IPCMS. Depuis, j’étudie la photoréactivité de molécules organiques en phase condensée, par spectroscopie UV-Vis femtoseconde, dans l’équipe « BIODYN », que je dirige depuis 2016. Promu Directeur de Recherche en 2019.

Recherches actuelles

Voir la page de l’équipe « BIODYN »

Parcours universitaire

  • 2010 : Habilitation à diriger des recherches: « Ultrafast molecular photophysics: from concepts to molecular interactions in biological systems and organic functional materials », Université de Strasbourg.
  • 2004 : Post-doctorat (bourse européenne Marie Curie), dans le groupe du Prof. Jook Walraven, à l’université d’ Amsterdam (Pays-Bas). Collision de condensats de Bose-Einstein de Rb ultrafroid.
  • 1999 – 2003 : Thèse de doctorat: « Photo-association de l’hélium métastable au voisinage de la condensation de Bose-Einstein et formation de dimères géants« , au Laboratoire Kastler-Brossel, Université Paris 6, Paris (France), sous la direction de Michèle Leduc et Claude Cohen-Tannoudji.
  • 1995 – 1999 : Elève à l’Ecole Normale Supérieure de Cachan (France). DEA (Master) de « Physique Statistique et phénomènes non linéaires » (Université de Lyon), et Agrégation de Physique.

Publications

[1]
X. Yang, M. Manathunga, S. Gozem, J. Léonard, T. Andruniów, M. Olivucci, Quantum–classical simulations of rhodopsin reveal excited-state population splitting and its effects on quantum efficiency, Nature Chemistry. Early Access (2022) 1–11. https://doi.org/10.1038/s41557-022-00892-6.
[1]
M. Paolino, M. Saletti, A. Reale, M. Licciardi, P. Varvara, A. Marquette, J. Léonard, C. Bonechi, A. Donati, G. Giorgi, G. Giuliani, B. Carlotti, F. Ortica, L. Latterini, M. Gentile, E. Paccagnini, M. Olivucci, A. Cappelli, Design, Synthesis and Characterization of a New Visible Light-Sensitive Molecular Switch and its PEGylation Towards a Self-Assembling Molecule., Chemistry-a European Journal. 28 (2022) e202201477. https://doi.org/10.1002/chem.202201477.
[1]
G. Fanciullo, I. Conti, P. Didier, A. Klymchenko, J. Léonard, M. Garavelli, I. Rivalta, Modelling quenching mechanisms of disordered molecular systems in the presence of molecular aggregates, Physical Chemistry Chemical Physics. 24 (2022) 1787–1794. https://doi.org/10.1039/d1cp04260b.
[1]
H.-N. Le, J. Brazard, G. Barnoin, S. Vincent, B.Y. Michel, J. Léonard, A. Burger, Control of Intermolecular Photoinduced Electron Transfer in Deoxyadenosine-Based Fluorescent Probes, Chemistry-a European Journal. 27 (2021) 1364–1373. https://doi.org/10.1002/chem.202003456.
[1]
A. Cannizzo, J. Léonard, S. Haacke, Ultrafast Functional Dynamics in Proteins: Local Molecular Reporters and Femtosecond 2D Spectroscopy, in: I. Burghardt, S. Haacke (Eds.), ULTRAFAST DYNAMICS AT THE NANOSCALE: BIOMOLECULES AND SUPRAMOLECULAR ASSEMBLIES, 2017: pp. 207–253.
[1]
K. Voltz, J. Léonard, P.T. Touceda, J. Conyard, Z. Chaker, A. Dejaegere, J. Godet, Y. Mély, S. Haacke, R.H. Stote, Quantitative sampling of conformational heterogeneity of a DNA hairpin using molecular dynamics simulations and ultrafast fluorescence spectroscopy, Nucleic Acids Research. 44 (2016) 3408–3419. https://doi.org/10.1093/nar/gkw077.
[1]
L. Liu, P. Eisenbrandt, T. Roland, M. Polkehn, P.-O. Schwartz, K. Bruchlos, B. Omiecienski, S. Ludwigs, N. Leclerc, E. Zaborova, J. Léonard, S. Méry, I. Burghardt, S. Haacke, Controlling Charge Separation and Recombination by Chemical Design in Donor-Acceptor Dyads, Physical Chemistry Chemical Physics. 18 (2016) 18536–18548. https://doi.org/10.1039/C6CP00644B.
[1]
D. Agathangelou, Y. Orozco-Gonzalez, M. del Carmen Marin, P.P. Roy, J. Brazard, H. Kandori, K.-H. Jung, J. Léonard, T. Buckup, N. Ferre, M. Olivucci, S. Haacke, Effect of point mutations on the ultrafast photo-isomerization of Anabaena sensory rhodopsin, in: Faraday Discussions, 2018: pp. 55–75. https://doi.org/10.1039/c7fd00200a.
[1]
T. Roland, V. Kemlin, J. Nillon, J.-S. Pelle, O. Crégut, J. Brazard, J. Léonard, S. Haacke, BOXCARS-geometry 2DES setup in the 300-340nm range with pulse-to-pulse phase correction at 50kHz, in: Cerullo, G and Ogilvie, J and Kartner, F and Khalil, M and Li, R (Ed.), XXI INTERNATIONAL CONFERENCE ON ULTRAFAST PHENOMENA 2018 (UP 2018), E D P SCIENCES, 2019. https://doi.org/10.1051/epjconf/201920501009.
[1]
L. Liu, D. Agathangelou, T. Roland, O. Crégut, T. Duchanois, M. Beley, J. Léonard, P. Gros, S. Haacke, High sensitivity fluorescence up-conversion spectroscopy of (MLCT)-M-3 emission of metal-organic complexes, in: Cerullo, G and Ogilvie, J and Kartner, F and Khalil, M and Li, R (Ed.), XXI INTERNATIONAL CONFERENCE ON ULTRAFAST PHENOMENA 2018 (UP 2018), E D P SCIENCES, 2019. https://doi.org/10.1051/epjconf/201920509009.
[1]
D. Agathangelou, Y. El-Khoury, J. Brazard, O. Crégut, S. Haacke, G. Cerullo, J. Léonard, Towards broadband two-Dimensional electronic spectroscopy with similar to 8 fs phase-locked pulses at 400 nm, in: Cerullo, G and Ogilvie, J and Kartner, F and Khalil, M and Li, R (Ed.), XXI INTERNATIONAL CONFERENCE ON ULTRAFAST PHENOMENA 2018 (UP 2018), E D P SCIENCES, 2019. https://doi.org/10.1051/epjconf/201920503006.
[1]
P. Gosset, G. Taupier, O. Crégut, J. Brazard, Y. Mely, K.-D. Dorkenoo, J. Léonard, P. Didier, Excited-State Proton Transfer in Oxyluciferin and Its Analogues, Journal of Physical Chemistry Letters. 11 (2020) 3653–3659. https://doi.org/10.1021/acs.jpclett.0c00839.
[1]
P. Didier, J. Kuchlyan, L. Martinez-Fernandez, P. Gosset, J. Léonard, Y. Tor, R. Improta, Y. Mely, Deciphering the pH-dependence of ground- and excited-state equilibria of thienoguanine, Physical Chemistry Chemical Physics. 22 (2020) 7381–7391. https://doi.org/10.1039/c9cp06931c.
[1]
D. Agathangelou, P.P. Roy, M. del C. Marin, N. Ferre, M. Olivucci, T. Buckup, J. Léonard, S. Haacke, Sub-picosecond C=C bond photo-isomerization: evidence for the role of excited state mixing, Comptes Rendus Physique. 22 (2021) 111–138. https://doi.org/10.5802/crphys.41.
[1]
N. Grytsyk, D. Cianfarani, O. Cregut, L. Richert, C. Boudier, N. Humbert, P. Didier, Y. Mely, J. Léonard, Kinetics of protein-assisted nucleic acid interconversion monitored by transient time resolved fluorescence in microfluidic droplets, Nucleic Acids Research. 49 (2021) e111. https://doi.org/10.1093/nar/gkab687.
[1]
T. Lieske, W. Uhring, N. Dumas, J. Léonard, D. Fey, Embedded Fluorescence Lifetime Determination for High Throughput Real-Time Droplet Sorting with Microfluidics, in: 2017 Conference on Design and Architectures for Signal and Image Processing (DASIP), IEEE, 2017: pp. 1–6. https://ieeexplore.ieee.org/document/8122129/.
[1]
J. Léonard, D. Rouxel, P. Hébraud, CNRS School “Nanophysics for Health”, 5-9 November 2012, Mittelwhir, France PREFACE, Journal of Nanobiotechnology. 11 (2013) 1. https://doi.org/10.1186/1477-3155-11-s1-i1.
[1]
J. Conyard, K. Voltz, T. Gelot, P. Touron-Touceda, O. Crégut, J. Léonard, R. Stote, S. Haacke, Local structural dynamics of DNA hairpins studied by ultrafast fluorescence spectroscopy and molecular dynamics simulations, in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014.
[1]
P.T. Touceda, T. Gelot, O. Crégut, J. Léonard, S. Haacke, Time-Resolved Down-Conversion of 2-Aminopurine in a DNA Hairpin: Fluorescence Anisotropy and Solvent Effects, in: M. Chergui, A. Taylor, S. Cundiff, R. DeVivieRiedle, K. Yamagouchi (Eds.), EPJ Web of Conferences, 2013: p. 07022 /p.1–3. https://doi.org/10.1051/epjconf/20134107022.
[1]
T. Gelot, P. Touron-Touceda, O. Crégut, J. Léonard, S. Haacke, Ultrafast Site-Specific Fluorescence Quenching of 2-Aminopurine in a DNA Hairpin Studied by Femtosecond Down-Conversion, Journal of Physical Chemistry A. 116 (2012) 2819–2825. https://doi.org/10.1021/jp212187m.
[1]
M. Paolino, T. Giovannini, M. Manathunga, L. Latterini, G. Zampini, R. Pierron, J. Léonard, S. Fusi, G. Giorgi, G. Giuliani, A. Cappelli, C. Cappelli, M. Olivucci, On the Transition from a Biomimetic Molecular Switch to a Rotary Molecular Motor, Journal of Physical Chemistry Letters. 12 (2021) 3875–3884. https://doi.org/10.1021/acs.jpclett.1c00526.
[1]
D.R.S. Pooler, R. Pierron, S. Crespi, R. Costil, L. Pfeifer, J. Léonard, M. Olivucci, B.L. Feringa, Effect of charge-transfer enhancement on the efficiency and rotary mechanism of an oxindole-based molecular motor, Chemical Science. 12 (2021) 7486–7497. https://doi.org/10.1039/d1sc01105g.
[1]
A.I. Skilitsi, D. Agathangelou, I. Shulov, J. Conyard, S. Haacke, Y. Mely, A. Klymchenko, J. Léonard, Ultrafast photophysics of the environment-sensitive 4[prime or minute]-methoxy-3-hydroxyflavone fluorescent dye, Physical Chemistry Chemical Physics. 20 (2018) 7885–7895. https://doi.org/10.1039/C7CP08584B.
[1]
M. Gueye, M. Manathunga, D. Agathangelou, Y. Orozco, M. Paolino, S. Fusi, S. Haacke, M. Olivucci, J. Léonard, Engineering the vibrational coherence of vision into a synthetic molecular device, Nature Communications. 9 (2018) 313. https://doi.org/10.1038/s41467-017-02668-w.
[1]
A.I. Skilitsi, T. Turko, D. Cianfarani, S. Barre, W. Uhring, U. Hassiepen, J. Léonard, Towards sensitive, high-throughput, biomolecular assays based on fluorescence lifetime, Methods and  Applications in Fluorescence. 5 (2017). https://doi.org/10.1088/2050-6120/aa7f66.
[1]
C. Garcia-Iriepa, M. Gueye, J. Léonard, D. Martinez-Lopez, P.J. Campos, L.M. Frutos, D. Sampedro, M. Marazzi, A biomimetic molecular switch at work: coupling photoisomerization dynamics to peptide structural rearrangement, Physical Chemistry Chemical Physics. 18 (2016) 6742–6753. https://doi.org/10.1039/C5CP07599H.
[1]
D. Nettels, D. Haenni, S. Maillot, M. Gueye, A. Barth, V. Hirschfeld, C.G. Huebner, J. Léonard, B. Schuler, Excited-state annihilation reduces power dependence of single-molecule FRET experiments, Physical Chemistry Chemical Physics. 17 (2015) 32304–32315. https://doi.org/10.1039/c5cp05321h.
[1]
G. Marchand, J. Eng, I. Schapiro, A. Valentini, L.M. Frutos, E. Pieri, M. Olivucci, J. Léonard, E. Gindensperger, Directionality of Double-Bond Photoisomerization Dynamics Induced by a Single Stereogenic Center, Journal of Physical Chemistry Letters. 6 (2015) 599–604. https://doi.org/10.1021/jz502644h.
[1]
A. Cheminal, J. Léonard, S.-Y. Kim, K.-H. Jung, H. Kandori, S. Haacke, 100 fs photo-isomerization with vibrational coherences but low quantum yield in Anabaena Sensory Rhodopsin, Physical Chemistry Chemical Physics. 17 (2015) 25429–25439. https://doi.org/10.1039/C5CP04353K.
[1]
S. Maillot, A. Carvalho, J.-P. Vola, C. Boudier, Y. Mely, S. Haacke, J. Léonard, Out-of-equilibrium biomolecular interactions monitored by picosecond fluorescence in microfluidic droplets, Lab on a Chip. 14 (2014) 1767–1774. https://doi.org/10.1039/C3LC51283E.
[1]
J. Léonard, N. Dumas, J.-P. Causse, S. Maillot, N. Giannakopoulou, S. Barre, W. Uhring, High-throughput time-correlated single photon counting, Lab on a Chip. 14 (2014) 4338–4343. https://doi.org/10.1039/C4LC00780H.
[1]
A. Cheminal, S.Y. Kim, J. Léonard, H. Kandori, K.H. Jung, S. Haacke, Anabaena sensory Rhodopsin: Excited state dynamics of a natural photoswitch studied by steady state fluorescence and ultrafast spectroscopy, in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Dallas, TX, USA, 2014.
[1]
J. Léonard, I. Schapiro, J. Briand, S. Fusi, R.R. Paccani, M. Olivucci, S. Haacke, Mechanistic Origin of the Vibrational Coherence Accompanying the Photoreaction of Biomimetic Molecular Switches, Chemistry-a European Journal. 18 (2012) 15296–15304. https://doi.org/10.1002/chem.201201430.
[1]
M. Olivucci, I. Schapiro, S. Haacke, J. Léonard, S. Fusi, R.R. Paccani, J. Briand, From computational photobiology to the design of vibrationally coherent molecular devices, in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012: pp. 272-COMP.
[1]
L. Donato, A. Mourot, C.M. Davenport, C. Herbivo, D. Warther, J. Léonard, F. Bolze, J.-F. Nicoud, R.H. Kramer, M. Goeldner, A. Specht, Water-Soluble, Donor-Acceptor Biphenyl Derivatives in the 2-(o-Nitrophenyl)propyl Series: Highly Efficient Two-Photon Uncaging of the Neurotransmitter gamma-Aminobutyric Acid at lambda=800 nm, Angewandte Chemie-International Edition. 51 (2012) 1840–1843. https://doi.org/10.1002/anie.201106559.
[1]
M. Gueye, S. Haacke, S. Fusi, M. Olivucci, E. Gindensperger, J. Léonard, Ultrafast Photoisomerization of Chiral Biomimetic Molecular Switches, in: Yamanouchi, I and Cundiff, S and DeVivieRiedle, R and KuwataGonokami, M and DiMauro, L (Ed.), Ultrafast Phenomena XIX, SPRINGER-VERLAG BERLIN, Okinawa, JAPAN, 7-11 juillet 2014, 2015: pp. 517–520. https://doi.org/10.1007/978-3-319-13242-6_126.
[1]
T. Schwartz, J.A. Hutchison, J. Léonard, C. Genet, S. Haacke, T.W. Ebbesen, Polariton Dynamics under Strong Light-Molecule Coupling, ChemPhysChem. 14 (2013) 125–131. https://doi.org/10.1002/cphc.201200734.
[1]
M. Ngueye, I. Schapiro, S. Fusi, S. Haacke, M. Olivucci, J. Léonard, Coherent Photoisomerization and Quantum Yield of Biomimetic Molecular Switches, in: 2013 Conference on Lasers and Electro-Optics Europe & International Quantum Electronics Conference (CLEO/Europe-IQEC), IEEE, 2013.
[1]
J. Léonard, D. Polli, G. Cerullo, M. Olivucci, S. Haacke, Influence of the Chemical Design on the Coherent Photoisomerization of Biomimetic Molecular Switches, in: M. Chergui, A. Taylor, S. Cundiff, R. DeVivieRiedle, K. Yamagouchi (Eds.), EPJ Web of Conferences, 2013: p. 05006 /p.1–3. https://doi.org/10.1051/epjconf/20134105006.
[1]
J. Léonard, J. Briand, S. Fusi, V. Zanirato, M. Olivucci, S. Haacke, Isomer-dependent vibrational coherence in ultrafast photoisomerization, New Journal of Physics. 15 (2013) 105022. https://doi.org/10.1088/1367-2630/15/10/105022.
[1]
A. Cheminal, J. Léonard, S.Y. Kim, K.H. Jung, H. Kandori, S. Haacke, Steady state emission of the fluorescent intermediate of Anabaena Sensory Rhodopsin as a function of light adaptation conditions, Chemical Physics Letters. 587 (2013) 75–80. https://doi.org/10.1016/j.cplett.2013.09.044.
[1]
C. Garcia-Iriepa, D. Sampedro, F. Mendicuti, J. Léonard, L. Manuel Frutos, Photoreactivity Control Mediated by Molecular Force Probes in Stilbene, Journal of Physical Chemistry Letters. 10 (2019) 1063–1067. https://doi.org/10.1021/acs.jpclett.8b03802.
[1]
T. Lieske, W. Uhring, N. Dumas, A.I. Skilitski, J. Léonard, D. Fey, Embedded Fluorescence Lifetime Determination for High-Throughput, Low-Photon-Number Applications, Journal of Signal Processing Systems for Signal Image and Video Technology. 91 (2019) 819–831. https://doi.org/10.1007/s11265-018-1372-9.
[1]
I. Schapiro, M. Gueye, M. Paolino, S. Fusi, G. Marchand, S. Haacke, M.E. Martin, M. Huntress, V.P. Vysotskiy, V. Veryazov, J. Léonard, M. Olivucci, Synthesis, spectroscopy and QM/MM simulations of a biomimetic ultrafast light-driven molecular motor, Photochemical & Photobiological Sciences. 18 (2019) 2259–2269. https://doi.org/10.1039/c9pp00223e.
[1]
M. Gueye, M. Paolino, E. Gindensperger, S. Haacke, M. Olivucci, J. Léonard, Vibrational coherence and quantum yield of retinal-chromophore-inspired molecular switches, Faraday Discussions. 221 (2020) 299–321. https://doi.org/10.1039/c9fd00062c.
[1]
Q. Wei, R. Duan, Q. Zhang, L. Xie, R. Xia, Y. Yi, J. Léonard, S. Haacke, J. Cabanillas-Gonzalez, Y. Qian, W. Huang, Origin of Intramolecular Low-Threshold Amplified Spontaneous Emission, Advanced Optical Materials. (2021) 2001956. https://doi.org/10.1002/adom.202001956.
[1]
T. Roland, J. Léonard, G.H. Ramirez, S. Méry, O. Yurchenko, S. Ludwigs, S. Haacke, Sub-100 fs charge transfer in a novel donor-acceptor-donor triad organized in a smectic film, Physical Chemistry Chemical Physics. 14 (2012) 273–279. https://doi.org/10.1039/c1cp22122a.
[1]
T. Roland, G.H. Ramirez, J. Léonard, S. Méry, S. Haacke, Ultrafast broadband laser spectroscopy reveals energy and charge transfer in novel donor-acceptor triads for photovoltaic applications, in: Ye, C and Wang, ZL and Zhou, B (Ed.), Journal of Physics: Conference Series, 2011: p. 012006 /p. 1–6. https://doi.org/10.1088/1742-6596/276/1/012006.