Biophysics and Dynamics of Organic Nanostructures (BioDyn)

The Biodyn team (Biophysics and ultrafast Dynamics) develops experimental tools for time-resolved spctroscopy and micromanipulation/microscopy in the fields of physical chemistry and biophysics.

We use ultrafast spectroscopy to investigate the photoreactivity of (bio)organic compounds and nanostructures. Typical processes of interest are photo-electric or photo-mechanical energy conversions at the molecular scale, which have applications in material science (e.g. photovoltaic devices, nanomachines), and are also exploited in biological systems (photosynthesis, vision). From the physical point of view, these processes rely on ultrafast, photoinduced energy and charge transfer or ultrafast photoinduced isomerization reactions in organic molecules interacting with their environment (solution, functional organic film, protein, etc…). We implement non-linear, femtosecond UV-Vis spectroscopy to investigate the mechanisms of such ultrafast processes.

Besides, the environment-sensitive photoreactivity of organic compounds may be exploited to probe local interactions in biomolecules. Hence one of our contributions to biophysics resides in exploiting time-resolved spectroscopy to unravel biomolecular structures or interactions.

Overmore, our biophysical research activity also focuses on the cellular or organism scales. To this end, we also develop microscopy and micromanipulation schemes (e.g. optical tweezers) to probe cell adhesion in the context of development biology or tumor progression.

Team members :

Doctorante, Ultrafast Optics and Nanophotonics (DON)amira.gharbi@ipcms.unistra.fr
Station: +33(0)3 88 10 71 88Office: 3001
Professeur de Recherche, Ultrafast Optics and Nanophotonics (DON)stefan.haacke@ipcms.unistra.fr
Station: +33(0)3 88 10 71 71, +33(0)3 88 10 70 54Office: 2029
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Directeur de Recherche, Ultrafast Optics and Nanophotonics (DON)jeremie.leonard@ipcms.unistra.fr
Station: +33(0)3 88 10 72 43, +33(0)3 88 10 70 54Office: 2052
Doctorant, Ultrafast Optics and Nanophotonics (DON)ilias.nikolinakos@ipcms.unistra.fr
Station: +33(0)3 88 10 71 88Office: 3001
Doctorant, Ultrafast Optics and Nanophotonics (DON)robin.pierron@ipcms.unistra.fr
Station: +33(0)3 88 10 71 95Office: 3009
The team in Oct. 2016

Recent publications :

[1]
M. Darari, A. Frances-Monerris, B. Marekha, A. Doudouh, E. Wenger, A. Monari, S. Haacke, P.C. Gros, Towards Iron(II) Complexes with Octahedral Geometry: Synthesis, Structure and Photophysical Properties, Molecules. 25 (2020) 5991. https://doi.org/10.3390/molecules25245991.
[1]
P. Didier, J. Kuchlyan, L. Martinez-Fernandez, P. Gosset, J. Léonard, Y. Tor, R. Improta, Y. Mely, Deciphering the pH-dependence of ground- and excited-state equilibria of thienoguanine, Physical Chemistry Chemical Physics. 22 (2020) 7381–7391. https://doi.org/10.1039/c9cp06931c.
[1]
P. Gosset, G. Taupier, O. Cregut, J. Brazard, Y. Mely, K.-D. Dorkenoo, J. Léonard, P. Didier, Excited-State Proton Transfer in Oxyluciferin and Its Analogues, Journal of Physical Chemistry Letters. 11 (2020) 3653–3659. https://doi.org/10.1021/acs.jpclett.0c00839.
[1]
M.L. Gruenbein, M. Stricker, G. Nass Kovacs, M. Kloos, R.B. Doak, R.L. Shoeman, J. Reinstein, S. Lecler, S. Haacke, I. Schlichting, Illumination guidelines for ultrafast pump-probe experiments by serial femtosecond crystallography, Nature Methods. early (2020). https://doi.org/10.1038/s41592-020-0847-3.
[1]
M. Gueye, M. Paolino, E. Gindensperger, S. Haacke, M. Olivucci, J. Léonard, Vibrational coherence and quantum yield of retinal-chromophore-inspired molecular switches, Faraday Discussions. 221 (2020) 299–321. https://doi.org/10.1039/c9fd00062c.
[1]
H.-N. Le, J. Brazard, G. Barnoin, S. Vincent, B.Y. Michel, J. Léonard, A. Burger, Control of Intermolecular Photoinduced Electron Transfer in Deoxyadenosine-Based Fluorescent Probes, Chemistry-a European Journal. 26 (2020) 1–11. https://doi.org/10.1002/chem.202003456.
[1]
J. Li, T. Wu, J. Zhang, S. Haacke, F. Teng, B. Hu, Exploring Light Polarization Effects of Photovoltaic Actions in Organic-Inorganic Hybrid Perovskites with Asymmetric and Symmetric Unit Structures, ACS Applied Materials & Interfaces. 12 (2020) 38054–38060. https://doi.org/10.1021/acsami.0c09276.
[1]
K. Magra, M. Darari, E. Domenichini, A. Frances-Monerris, C. Cebrian, M. Beley, M. Pastore, A. Monari, X. Assfeld, S. Haacke, P.C. Gros, Photophysical Investigation of Iron(II) Complexes Bearing Bidentate Annulated Isomeric Pyridine-NHC Ligands, Journal of Physical Chemistry C. 124 (2020) 18379–18389. https://doi.org/10.1021/acs.jpcc.0c03638.
[1]
M. Manathunga, A.J. Jenkins, Y. Orozco-Gonzalez, A. Ghanbarpour, B. Borhan, J.H. Geiger, D.S. Larsen, M. Olivucci, Computational and Spectroscopic Characterization of the Photocycle of an Artificial Rhodopsin, Journal of Physical Chemistry Letters. 11 (2020) 4245–4252. https://doi.org/10.1021/acs.jpclett.0c00751.
[1]
M.A. Naumova, A. Kalinko, J.W.L. Wong, M. Abdellah, H. Geng, E. Domenichini, J. Meng, S.A. Gutierrez, P.-A. Mante, W. Lin, P. Zalden, A. Galler, F. Lima, K. Kubicek, M. Biednov, A. Britz, S. Checchia, V. Kabanova, M. Wulff, J. Zimara, D. Schwarzer, S. Demeshko, V. Murzin, D. Gosztola, M. Jarenmark, J. Zhang, M. Bauer, M.L.L. Daku, W. Gawelda, D. Khakhulin, C. Bressler, F. Meyer, K. Zheng, S.E. Canton, Revealing Hot and Long-Lived Metastable Spin States in the Photoinduced Switching of Solvated Metallogrid Complexes with Femtosecond Optical and X-ray Spectroscopies, Journal of Physical Chemistry Letters. 11 (2020) 2133–2141. https://doi.org/10.1021/acs.jpclett.9b03883.
[1]
M. Wang, H. Zou, J. Zhang, T. Wu, H. Xu, S. Haacke, B. Hu, Extremely Long Spin Lifetime of Light-Emitting States in Quasi-2D Perovskites through Orbit-Orbit Interaction, Journal of Physical Chemistry Letters. 11 (2020) 3647–3652. https://doi.org/10.1021/acs.jpclett.0c00842.

Femtosecond Instrumentation

New Tools for Biophotonics

Photophysics of organic nanostructures for energy conversion applications

Biomolecular Structural Heterogeneity and Dynamics studied by ultrafast spectroscopy

Ultrafast photo-isomerization