Jérémie LEONARD

Jérémie LEONARD

Senior Researcher, Ultrafast Optics and Nanophotonics (DON)Jeremie.Leonard@ipcms.unistra.fr
Phone: +33(0)3 88 10 72 43, +33(0)3 88 10 70 54Office: 2042

Research background

After a PhD work and a post-doctoral fellowship in the field of ultracold gases and Bose-Einstein condensation, I was appointed at CNRS as “Chargé de Recherche” in 2004, in the Department of ultrafast Optics and Nanophotonics (DON) at IPCMS. Since then, I have been investigating ultrafast (bio)molecular photoreactions using UV-Vis femtosecond spectroscopy in the “BIODYN” team, which I lead since 2016. I was promoted “Directeur de Recherche” in 2019.

Current researches

See the“BIODYN” team web page.

Academic background

  • 2010 : Habilitation à diriger des recherches: “Ultrafast molecular photophysics: from concepts to molecular interactions in biological systems and organic functional materials”, Université de Strasbourg.
  • 2004 : European Marie Curie postdoctoral fellowship, in the group of Prof. Jook Walraven, at the University of Amsterdam (The Netherlands). Collision of Rb Bose-Einstein condensates.
  • 1999 – 2003 : PhD thesis: “Photo-association de l’hélium métastable au voisinage de la condensation de Bose-Einstein et formation de dimères géants“, at Laboratoire Kastler-Brossel, Université Paris 6, Paris (France), with Michèle Leduc and Claude Cohen-Tannoudji.
  • 1995 – 1999 : Education in Physics at Ecole Normale Supérieure de Cachan (France). Master degree in “Statistical physics and nonlinear Phenomena” (Université de Lyon), and “Agrégation de Physique”.

Publications

[1]
X. Yang, M. Manathunga, S. Gozem, J. Léonard, T. Andruniów, M. Olivucci, Quantum–classical simulations of rhodopsin reveal excited-state population splitting and its effects on quantum efficiency, Nature Chemistry. Early Access (2022) 1–11. https://doi.org/10.1038/s41557-022-00892-6.
[1]
M. Paolino, M. Saletti, A. Reale, M. Licciardi, P. Varvara, A. Marquette, J. Léonard, C. Bonechi, A. Donati, G. Giorgi, G. Giuliani, B. Carlotti, F. Ortica, L. Latterini, M. Gentile, E. Paccagnini, M. Olivucci, A. Cappelli, Design, Synthesis and Characterization of a New Visible Light-Sensitive Molecular Switch and its PEGylation Towards a Self-Assembling Molecule., Chemistry-a European Journal. 28 (2022) e202201477. https://doi.org/10.1002/chem.202201477.
[1]
G. Fanciullo, I. Conti, P. Didier, A. Klymchenko, J. Léonard, M. Garavelli, I. Rivalta, Modelling quenching mechanisms of disordered molecular systems in the presence of molecular aggregates, Physical Chemistry Chemical Physics. 24 (2022) 1787–1794. https://doi.org/10.1039/d1cp04260b.
[1]
H.-N. Le, J. Brazard, G. Barnoin, S. Vincent, B.Y. Michel, J. Léonard, A. Burger, Control of Intermolecular Photoinduced Electron Transfer in Deoxyadenosine-Based Fluorescent Probes, Chemistry-a European Journal. 27 (2021) 1364–1373. https://doi.org/10.1002/chem.202003456.
[1]
A. Cannizzo, J. Léonard, S. Haacke, Ultrafast Functional Dynamics in Proteins: Local Molecular Reporters and Femtosecond 2D Spectroscopy, in: I. Burghardt, S. Haacke (Eds.), ULTRAFAST DYNAMICS AT THE NANOSCALE: BIOMOLECULES AND SUPRAMOLECULAR ASSEMBLIES, 2017: pp. 207–253.
[1]
K. Voltz, J. Léonard, P.T. Touceda, J. Conyard, Z. Chaker, A. Dejaegere, J. Godet, Y. Mély, S. Haacke, R.H. Stote, Quantitative sampling of conformational heterogeneity of a DNA hairpin using molecular dynamics simulations and ultrafast fluorescence spectroscopy, Nucleic Acids Research. 44 (2016) 3408–3419. https://doi.org/10.1093/nar/gkw077.
[1]
L. Liu, P. Eisenbrandt, T. Roland, M. Polkehn, P.-O. Schwartz, K. Bruchlos, B. Omiecienski, S. Ludwigs, N. Leclerc, E. Zaborova, J. Léonard, S. Méry, I. Burghardt, S. Haacke, Controlling Charge Separation and Recombination by Chemical Design in Donor-Acceptor Dyads, Physical Chemistry Chemical Physics. 18 (2016) 18536–18548. https://doi.org/10.1039/C6CP00644B.
[1]
D. Agathangelou, Y. Orozco-Gonzalez, M. del Carmen Marin, P.P. Roy, J. Brazard, H. Kandori, K.-H. Jung, J. Léonard, T. Buckup, N. Ferre, M. Olivucci, S. Haacke, Effect of point mutations on the ultrafast photo-isomerization of Anabaena sensory rhodopsin, in: Faraday Discussions, 2018: pp. 55–75. https://doi.org/10.1039/c7fd00200a.
[1]
T. Roland, V. Kemlin, J. Nillon, J.-S. Pelle, O. Crégut, J. Brazard, J. Léonard, S. Haacke, BOXCARS-geometry 2DES setup in the 300-340nm range with pulse-to-pulse phase correction at 50kHz, in: Cerullo, G and Ogilvie, J and Kartner, F and Khalil, M and Li, R (Ed.), XXI INTERNATIONAL CONFERENCE ON ULTRAFAST PHENOMENA 2018 (UP 2018), E D P SCIENCES, 2019. https://doi.org/10.1051/epjconf/201920501009.
[1]
L. Liu, D. Agathangelou, T. Roland, O. Crégut, T. Duchanois, M. Beley, J. Léonard, P. Gros, S. Haacke, High sensitivity fluorescence up-conversion spectroscopy of (MLCT)-M-3 emission of metal-organic complexes, in: Cerullo, G and Ogilvie, J and Kartner, F and Khalil, M and Li, R (Ed.), XXI INTERNATIONAL CONFERENCE ON ULTRAFAST PHENOMENA 2018 (UP 2018), E D P SCIENCES, 2019. https://doi.org/10.1051/epjconf/201920509009.
[1]
D. Agathangelou, Y. El-Khoury, J. Brazard, O. Crégut, S. Haacke, G. Cerullo, J. Léonard, Towards broadband two-Dimensional electronic spectroscopy with similar to 8 fs phase-locked pulses at 400 nm, in: Cerullo, G and Ogilvie, J and Kartner, F and Khalil, M and Li, R (Ed.), XXI INTERNATIONAL CONFERENCE ON ULTRAFAST PHENOMENA 2018 (UP 2018), E D P SCIENCES, 2019. https://doi.org/10.1051/epjconf/201920503006.
[1]
P. Gosset, G. Taupier, O. Crégut, J. Brazard, Y. Mely, K.-D. Dorkenoo, J. Léonard, P. Didier, Excited-State Proton Transfer in Oxyluciferin and Its Analogues, Journal of Physical Chemistry Letters. 11 (2020) 3653–3659. https://doi.org/10.1021/acs.jpclett.0c00839.
[1]
P. Didier, J. Kuchlyan, L. Martinez-Fernandez, P. Gosset, J. Léonard, Y. Tor, R. Improta, Y. Mely, Deciphering the pH-dependence of ground- and excited-state equilibria of thienoguanine, Physical Chemistry Chemical Physics. 22 (2020) 7381–7391. https://doi.org/10.1039/c9cp06931c.
[1]
D. Agathangelou, P.P. Roy, M. del C. Marin, N. Ferre, M. Olivucci, T. Buckup, J. Léonard, S. Haacke, Sub-picosecond C=C bond photo-isomerization: evidence for the role of excited state mixing, Comptes Rendus Physique. 22 (2021) 111–138. https://doi.org/10.5802/crphys.41.
[1]
N. Grytsyk, D. Cianfarani, O. Cregut, L. Richert, C. Boudier, N. Humbert, P. Didier, Y. Mely, J. Léonard, Kinetics of protein-assisted nucleic acid interconversion monitored by transient time resolved fluorescence in microfluidic droplets, Nucleic Acids Research. 49 (2021) e111. https://doi.org/10.1093/nar/gkab687.
[1]
T. Lieske, W. Uhring, N. Dumas, J. Léonard, D. Fey, Embedded Fluorescence Lifetime Determination for High Throughput Real-Time Droplet Sorting with Microfluidics, in: 2017 Conference on Design and Architectures for Signal and Image Processing (DASIP), IEEE, 2017: pp. 1–6. https://ieeexplore.ieee.org/document/8122129/.
[1]
J. Léonard, D. Rouxel, P. Hébraud, CNRS School “Nanophysics for Health”, 5-9 November 2012, Mittelwhir, France PREFACE, Journal of Nanobiotechnology. 11 (2013) 1. https://doi.org/10.1186/1477-3155-11-s1-i1.
[1]
J. Conyard, K. Voltz, T. Gelot, P. Touron-Touceda, O. Crégut, J. Léonard, R. Stote, S. Haacke, Local structural dynamics of DNA hairpins studied by ultrafast fluorescence spectroscopy and molecular dynamics simulations, in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014.
[1]
P.T. Touceda, T. Gelot, O. Crégut, J. Léonard, S. Haacke, Time-Resolved Down-Conversion of 2-Aminopurine in a DNA Hairpin: Fluorescence Anisotropy and Solvent Effects, in: M. Chergui, A. Taylor, S. Cundiff, R. DeVivieRiedle, K. Yamagouchi (Eds.), EPJ Web of Conferences, 2013: p. 07022 /p.1–3. https://doi.org/10.1051/epjconf/20134107022.
[1]
T. Gelot, P. Touron-Touceda, O. Crégut, J. Léonard, S. Haacke, Ultrafast Site-Specific Fluorescence Quenching of 2-Aminopurine in a DNA Hairpin Studied by Femtosecond Down-Conversion, Journal of Physical Chemistry A. 116 (2012) 2819–2825. https://doi.org/10.1021/jp212187m.
[1]
M. Paolino, T. Giovannini, M. Manathunga, L. Latterini, G. Zampini, R. Pierron, J. Léonard, S. Fusi, G. Giorgi, G. Giuliani, A. Cappelli, C. Cappelli, M. Olivucci, On the Transition from a Biomimetic Molecular Switch to a Rotary Molecular Motor, Journal of Physical Chemistry Letters. 12 (2021) 3875–3884. https://doi.org/10.1021/acs.jpclett.1c00526.
[1]
D.R.S. Pooler, R. Pierron, S. Crespi, R. Costil, L. Pfeifer, J. Léonard, M. Olivucci, B.L. Feringa, Effect of charge-transfer enhancement on the efficiency and rotary mechanism of an oxindole-based molecular motor, Chemical Science. 12 (2021) 7486–7497. https://doi.org/10.1039/d1sc01105g.
[1]
A.I. Skilitsi, D. Agathangelou, I. Shulov, J. Conyard, S. Haacke, Y. Mely, A. Klymchenko, J. Léonard, Ultrafast photophysics of the environment-sensitive 4[prime or minute]-methoxy-3-hydroxyflavone fluorescent dye, Physical Chemistry Chemical Physics. 20 (2018) 7885–7895. https://doi.org/10.1039/C7CP08584B.
[1]
M. Gueye, M. Manathunga, D. Agathangelou, Y. Orozco, M. Paolino, S. Fusi, S. Haacke, M. Olivucci, J. Léonard, Engineering the vibrational coherence of vision into a synthetic molecular device, Nature Communications. 9 (2018) 313. https://doi.org/10.1038/s41467-017-02668-w.
[1]
A.I. Skilitsi, T. Turko, D. Cianfarani, S. Barre, W. Uhring, U. Hassiepen, J. Léonard, Towards sensitive, high-throughput, biomolecular assays based on fluorescence lifetime, Methods and  Applications in Fluorescence. 5 (2017). https://doi.org/10.1088/2050-6120/aa7f66.
[1]
C. Garcia-Iriepa, M. Gueye, J. Léonard, D. Martinez-Lopez, P.J. Campos, L.M. Frutos, D. Sampedro, M. Marazzi, A biomimetic molecular switch at work: coupling photoisomerization dynamics to peptide structural rearrangement, Physical Chemistry Chemical Physics. 18 (2016) 6742–6753. https://doi.org/10.1039/C5CP07599H.
[1]
D. Nettels, D. Haenni, S. Maillot, M. Gueye, A. Barth, V. Hirschfeld, C.G. Huebner, J. Léonard, B. Schuler, Excited-state annihilation reduces power dependence of single-molecule FRET experiments, Physical Chemistry Chemical Physics. 17 (2015) 32304–32315. https://doi.org/10.1039/c5cp05321h.
[1]
G. Marchand, J. Eng, I. Schapiro, A. Valentini, L.M. Frutos, E. Pieri, M. Olivucci, J. Léonard, E. Gindensperger, Directionality of Double-Bond Photoisomerization Dynamics Induced by a Single Stereogenic Center, Journal of Physical Chemistry Letters. 6 (2015) 599–604. https://doi.org/10.1021/jz502644h.
[1]
A. Cheminal, J. Léonard, S.-Y. Kim, K.-H. Jung, H. Kandori, S. Haacke, 100 fs photo-isomerization with vibrational coherences but low quantum yield in Anabaena Sensory Rhodopsin, Physical Chemistry Chemical Physics. 17 (2015) 25429–25439. https://doi.org/10.1039/C5CP04353K.
[1]
S. Maillot, A. Carvalho, J.-P. Vola, C. Boudier, Y. Mely, S. Haacke, J. Léonard, Out-of-equilibrium biomolecular interactions monitored by picosecond fluorescence in microfluidic droplets, Lab on a Chip. 14 (2014) 1767–1774. https://doi.org/10.1039/C3LC51283E.
[1]
J. Léonard, N. Dumas, J.-P. Causse, S. Maillot, N. Giannakopoulou, S. Barre, W. Uhring, High-throughput time-correlated single photon counting, Lab on a Chip. 14 (2014) 4338–4343. https://doi.org/10.1039/C4LC00780H.
[1]
A. Cheminal, S.Y. Kim, J. Léonard, H. Kandori, K.H. Jung, S. Haacke, Anabaena sensory Rhodopsin: Excited state dynamics of a natural photoswitch studied by steady state fluorescence and ultrafast spectroscopy, in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Dallas, TX, USA, 2014.
[1]
J. Léonard, I. Schapiro, J. Briand, S. Fusi, R.R. Paccani, M. Olivucci, S. Haacke, Mechanistic Origin of the Vibrational Coherence Accompanying the Photoreaction of Biomimetic Molecular Switches, Chemistry-a European Journal. 18 (2012) 15296–15304. https://doi.org/10.1002/chem.201201430.
[1]
M. Olivucci, I. Schapiro, S. Haacke, J. Léonard, S. Fusi, R.R. Paccani, J. Briand, From computational photobiology to the design of vibrationally coherent molecular devices, in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012: pp. 272-COMP.
[1]
L. Donato, A. Mourot, C.M. Davenport, C. Herbivo, D. Warther, J. Léonard, F. Bolze, J.-F. Nicoud, R.H. Kramer, M. Goeldner, A. Specht, Water-Soluble, Donor-Acceptor Biphenyl Derivatives in the 2-(o-Nitrophenyl)propyl Series: Highly Efficient Two-Photon Uncaging of the Neurotransmitter gamma-Aminobutyric Acid at lambda=800 nm, Angewandte Chemie-International Edition. 51 (2012) 1840–1843. https://doi.org/10.1002/anie.201106559.
[1]
M. Gueye, S. Haacke, S. Fusi, M. Olivucci, E. Gindensperger, J. Léonard, Ultrafast Photoisomerization of Chiral Biomimetic Molecular Switches, in: Yamanouchi, I and Cundiff, S and DeVivieRiedle, R and KuwataGonokami, M and DiMauro, L (Ed.), Ultrafast Phenomena XIX, SPRINGER-VERLAG BERLIN, Okinawa, JAPAN, 7-11 juillet 2014, 2015: pp. 517–520. https://doi.org/10.1007/978-3-319-13242-6_126.
[1]
T. Schwartz, J.A. Hutchison, J. Léonard, C. Genet, S. Haacke, T.W. Ebbesen, Polariton Dynamics under Strong Light-Molecule Coupling, ChemPhysChem. 14 (2013) 125–131. https://doi.org/10.1002/cphc.201200734.
[1]
M. Ngueye, I. Schapiro, S. Fusi, S. Haacke, M. Olivucci, J. Léonard, Coherent Photoisomerization and Quantum Yield of Biomimetic Molecular Switches, in: 2013 Conference on Lasers and Electro-Optics Europe & International Quantum Electronics Conference (CLEO/Europe-IQEC), IEEE, 2013.
[1]
J. Léonard, D. Polli, G. Cerullo, M. Olivucci, S. Haacke, Influence of the Chemical Design on the Coherent Photoisomerization of Biomimetic Molecular Switches, in: M. Chergui, A. Taylor, S. Cundiff, R. DeVivieRiedle, K. Yamagouchi (Eds.), EPJ Web of Conferences, 2013: p. 05006 /p.1–3. https://doi.org/10.1051/epjconf/20134105006.
[1]
J. Léonard, J. Briand, S. Fusi, V. Zanirato, M. Olivucci, S. Haacke, Isomer-dependent vibrational coherence in ultrafast photoisomerization, New Journal of Physics. 15 (2013) 105022. https://doi.org/10.1088/1367-2630/15/10/105022.
[1]
A. Cheminal, J. Léonard, S.Y. Kim, K.H. Jung, H. Kandori, S. Haacke, Steady state emission of the fluorescent intermediate of Anabaena Sensory Rhodopsin as a function of light adaptation conditions, Chemical Physics Letters. 587 (2013) 75–80. https://doi.org/10.1016/j.cplett.2013.09.044.
[1]
C. Garcia-Iriepa, D. Sampedro, F. Mendicuti, J. Léonard, L. Manuel Frutos, Photoreactivity Control Mediated by Molecular Force Probes in Stilbene, Journal of Physical Chemistry Letters. 10 (2019) 1063–1067. https://doi.org/10.1021/acs.jpclett.8b03802.
[1]
T. Lieske, W. Uhring, N. Dumas, A.I. Skilitski, J. Léonard, D. Fey, Embedded Fluorescence Lifetime Determination for High-Throughput, Low-Photon-Number Applications, Journal of Signal Processing Systems for Signal Image and Video Technology. 91 (2019) 819–831. https://doi.org/10.1007/s11265-018-1372-9.
[1]
I. Schapiro, M. Gueye, M. Paolino, S. Fusi, G. Marchand, S. Haacke, M.E. Martin, M. Huntress, V.P. Vysotskiy, V. Veryazov, J. Léonard, M. Olivucci, Synthesis, spectroscopy and QM/MM simulations of a biomimetic ultrafast light-driven molecular motor, Photochemical & Photobiological Sciences. 18 (2019) 2259–2269. https://doi.org/10.1039/c9pp00223e.
[1]
M. Gueye, M. Paolino, E. Gindensperger, S. Haacke, M. Olivucci, J. Léonard, Vibrational coherence and quantum yield of retinal-chromophore-inspired molecular switches, Faraday Discussions. 221 (2020) 299–321. https://doi.org/10.1039/c9fd00062c.
[1]
Q. Wei, R. Duan, Q. Zhang, L. Xie, R. Xia, Y. Yi, J. Léonard, S. Haacke, J. Cabanillas-Gonzalez, Y. Qian, W. Huang, Origin of Intramolecular Low-Threshold Amplified Spontaneous Emission, Advanced Optical Materials. (2021) 2001956. https://doi.org/10.1002/adom.202001956.
[1]
T. Roland, J. Léonard, G.H. Ramirez, S. Méry, O. Yurchenko, S. Ludwigs, S. Haacke, Sub-100 fs charge transfer in a novel donor-acceptor-donor triad organized in a smectic film, Physical Chemistry Chemical Physics. 14 (2012) 273–279. https://doi.org/10.1039/c1cp22122a.
[1]
T. Roland, G.H. Ramirez, J. Léonard, S. Méry, S. Haacke, Ultrafast broadband laser spectroscopy reveals energy and charge transfer in novel donor-acceptor triads for photovoltaic applications, in: Ye, C and Wang, ZL and Zhou, B (Ed.), Journal of Physics: Conference Series, 2011: p. 012006 /p. 1–6. https://doi.org/10.1088/1742-6596/276/1/012006.