Biophysics and soft matter (BIOSOFT)

Research Activities :

Suspensions and powders 

The flow properties of suspensions of colloidal particles depart from simple Newtonian behavior at high shear rate, high volume fraction or when the colloidal particles interact. We study the mechanical properties of suspensions in such conditions, aiming at correlating them to their organization at the particle scale. When the suspension is concentrated enough, the suspension forms granulates: we study the mixing of a powder with a liquid and in particular the mechanisms at play in the granulates imbibition.

Cell mechanics 

Cells are mechanically active systems: they respond non-linearly to external stimuli and exert forces onto their environment. We determine the field of forces exerted by a cell onto a soft substrate by measuring the field of deformation of the substrate. We then correlate the observed mechanical properties with the cell phenotype.

Gene regulation

The level of proteins is highly regulated at different stages: activators may change the affinity of RNApol for specific promoters, small non coding RNA molecules can bind mRNA (and facilitate the recruitment of RNAses) or bind RBS sequences (and alter translation). Using single-molecule techniques, we study fundamental biological processes and their implication in the regulation of gene expression.

You can find much more information on our page

Team members :

Maître de conférences, Ultrafast Optics and Nanophotonics (DON)wilfried.grange@ipcms.unistra.fr
Station: +33(0)3 88 10 70 89Office: 1028
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Directeur de Recherche, Ultrafast Optics and Nanophotonics (DON)pascal.hebraud@ipcms.unistra.fr
Station: +33(0)3 88 10 71 85Office: 2403
Ingénieure d'Etude, Ultrafast Optics and Nanophotonics (DON)marie-noelle.lalloz@ipcms.unistra.fr
Station: +33(0)3 88 10 72 08Office: 3407
Doctorant, Ultrafast Optics and Nanophotonics (DON)saeel.momin@ipcms.unistra.fr
Station: +33(0)3 88 10 71 94Office: 2405
Picture from 2015

Publications :

A list of our publications can be found here.